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Posted: Wednesday, March 7, 2018 11:33 AM


The Clinical Pharmacology & Pharmacometrics (CPP) group is seeking for outstanding candidates for 2 postdoctoral positions with a term of 2-3 years. in pharmacometrics (exposure-response modeling with imaging outcomes). Both positions offer unique opportunity to work as part of a multidisciplinary team to facilitate all stages of CNS drug development, and is focused on the application of PK/PD mechanistic modeling and simulation to characterize PK and PD of novel modalities. These are ideal opportunities for individuals with quantitative background and affinity to biomedical problems to attain deep specialization and expertise in clinical pharmacology and drug development.
Postdoctoral Job Descriptions:
• Clinical Pharmacology and Pharmacometrics, Modeling Imaging Outcomes

Multiple neurology programs in Biogen are targeted at modifying the natural turnover of harmful proteins. The CPP function develops models relating the exposure (PK) to the time course of target protein. Understanding of and incorporating information for the natural turnover rate of the target proteins in these models is essential for the evaluation of the biological and disease-related activity of our drug candidates. We are looking for a motivated candidate to become a part of the joint effort between CPP and Biomarker Center of Excellence to integrate model derived knowledge about the target proteins in the existing mechanistic PK-PD models based on early phase clinical data. The methodology developed will be validated with data from number of drug development programs. Such methodology has not been critically and comprehensively evaluated in the existing literature, so it will represent significant scientific novelty, and can be published extensively. The project scope includes performing hands-on preclinical, translational and clinical modeling tasks using nonlinear mixed effects and physiologically-based modeling techniques to support dose selection, optimization and clinical trial design.

• Clinical Pharmacology and Pharmacometrics, Gene Therapy
Gene therapy began 20 years ago and over a thousand clinical trials have been carried out. In the field of clinical pharmacology and pharmacometrics, gene therapy is a novel modality with sparse literature. While the concept of “drug” continuously evolve from pills to biotechnology, it is expected that PK/PD concepts and models that have proved to be crucial in the understanding and prediction of effects of traditional drugs can also be extended to gene therapy. We are looking for a motivated candidate to support the scientific investigation and PK/PD modeling efforts for Adeno-Associated Virus (AAV)-based gene therapy platform across therapeutic areas at Biogen. The project scope includes designing fit-for-purpose PK/PD studies, performing hands-on preclinical, translational and clinical modeling projects using nonlinear mixed effects and physiologically-based modeling techniques to support dose selection, optimization and clinical trial design. The methodologies used in PK/PD of tradition drug modalities have not been evaluated for AAV-based gene therapy in the existing literature, so this project entails significant and clinically meaningful innovation in both the scientific and medical communities.
For both positions, the successful candidate should have a strong interest in developing novel methods and creative problem solving in PK/PD modeling and simulation. This candidate will be an integral part of CPP and work in close collaboration with scientific experts from preclinical and clinical drug development. During this fellowship, this candidate will have a full and diverse immersion in all stages of drug development at the cutting edge of biotechnology, and an opportunity to make an impactful contribution on the development of novel therapeutics in Alzheimer and other neurodegenerative diseases in the discipline of clinical pharmacology and pharmacometrics.
• Must have a doctoral degree in Applied mathematics, Pharmacometrics, Biomedical or Chemical Engineering, Pharmaceutical Sciences, or a closely related discipline
• Previous experience in modeling and simulation using PK/PD data with hands-on familiarity in Phoenix WinNonlin, NONMEM, R, Monolix is preferred.
• Previous experience in CNS biomedical research is preferred, but not required.
• Team player and effective communicator with the ability to contribute independently
• Publication record at conferences and/or peer reviewed journals
Recent PhD in Pharmacometrics, Applied mathematics, Biomedical or Chemical Engineering, Pharmaceutical Sciences, or a closely related discipline. These positions are an excellent opportunity for somebody with quantitative skills and wider biology exposure to get special focus in clinical pharmacology and pharmacokinetics.

Employment Category
Full-Time Regular
Ivan Nestorov ( or Lilly East ( ).

About Biogen
Biogen is one of the pioneers in biotechnology. Biogen has the leading portfolio of medicines to treat multiple sclerosis (MS), has the first and only approved treatment for spinal muscular atrophy (SMA) and is at the forefront of research into new medicines for neurological and neurodegenerative conditions. Led by world-class research and development, Biogen uses novel science and leading-edge technologies to create, commercialize, and manufacture transformative therapies for patients with few or no treatment options.

• Location: Boston

• Post ID: 57761827 boston is an interactive computer service that enables access by multiple users and should not be treated as the publisher or speaker of any information provided by another information content provider. © 2018